Pfizer/Moderna Vaccine

TEXASBGE2018

Ehh I won’t be eligible for a while so I’ve got time to think about it. Asking you smart doctor folk how fast would we typically see side effects once it is reaching levels of say 1M people inoculated? Also once we find those side effects how soon can we determine who is at risk for those side effects and how severe are they? Are we talking years for this to be visible or months?

I’m making the assumption that they have “estimates” based on clinical trials but I’m also assuming once it’s in the general population in greater numbers those estimates begin to solidify. I don’t want to take anything that could cause issues later but I also want to get over this shitefest we are currently in now.

nolaegghead

JohnInCarolina said:

nolaegghead said:

At least we're not getting Sputnik or whatever the Russian vaccine is....they say no drinking for a month or two after vaccination or it's not as effective.  I'm sure that's just another way of getting their people to not take an ineffective vaccine.

I saw that and just assumed Vlad had some ulterior motive, like trying to hide a pending vodka shortage from the population or something.  

Could you imagine whatever number of alcoholics in Russia going through DTs simultaneously?  This is the stuff that overthrows governments.

ColbyLang

Put me in the maybe pile. Let’s see how the round 1-4 guinea pigs come thru. If there are little to no issues, count me in. I, like others, worry about long term side effects. 8 months to market is very impressive in the pharma game. 

Anyone else realize that Pfizer owns the lab where the virus originated? Hmmmmm

JohnInCarolina

TEXASBGE2018 said:

Ehh I won’t be eligible for a while so I’ve got time to think about it. Asking you smart doctor folk how fast would we typically see side effects once it is reaching levels of say 1M people inoculated? Also once we find those side effects how soon can we determine who is at risk for those side effects and how severe are they? Are we talking years for this to be visible or months?

I’m making the assumption that they have “estimates” based on clinical trials but I’m also assuming once it’s in the general population in greater numbers those estimates begin to solidify. I don’t want to take anything that could cause issues later but I also want to get over this shitefest we are currently in now.

I don't think the issue is so much side effects - those are kind of always there with vaccines, things like headaches, sore arms, and etc. that are bothersome but largely temporary.  I'm pretty sure these vaccines have those.

I think probably what you're asking about are like truly adverse side effects like someone getting so sick in response to the vaccine that they actually had to be hospitalized, or something like that, right?

My understanding from what I've read is that the number of instances of things like that is really very low from people who were in the trials.  Given the numbers (tens of thousands) I would think we would know from the study data were those a significant concern, statistically.  But some of the MDs here can probably say a lot more.  

nolaegghead

ColbyLang said:

Anyone else realize that Pfizer owns the lab where the virus originated? Hmmmmm

Where is that a fact other than the conspiracy theory wack job Earth 2?

ColbyLang

nolaegghead said:

ColbyLang said:

Anyone else realize that Pfizer owns the lab where the virus originated? Hmmmmm

Where is that a fact other than the conspiracy theory wack job Earth 2?

Hey man, Fox News. We report, you decide. 

PS, I know it’s a false statement. Just bored on a Monday. Seeing who would bite

nolaegghead

JohnInCarolina said:

TEXASBGE2018 said:

Ehh I won’t be eligible for a while so I’ve got time to think about it. Asking you smart doctor folk how fast would we typically see side effects once it is reaching levels of say 1M people inoculated? Also once we find those side effects how soon can we determine who is at risk for those side effects and how severe are they? Are we talking years for this to be visible or months?

I’m making the assumption that they have “estimates” based on clinical trials but I’m also assuming once it’s in the general population in greater numbers those estimates begin to solidify. I don’t want to take anything that could cause issues later but I also want to get over this shitefest we are currently in now.

I don't think the issue is so much side effects - those are kind of always there with vaccines, things like headaches, sore arms, and etc. that are bothersome but largely temporary.  I'm pretty sure these vaccines have those.

I think probably what you're asking about are like truly adverse side effects like someone getting so sick in response to the vaccine that they actually had to be hospitalized, or something like that, right?

My understanding from what I've read is that the number of instances of things like that is really very low from people who were in the trials.  Given the numbers (tens of thousands) I would think we would know from the study data were those a significant concern, statistically.  But some of the MDs here can probably say a lot more.  

They found 2 people have severe allergic reactions to the vaccine in the UK.  Both people carried epi-pens because of a history of anaphylactic shock.

nolaegghead

ColbyLang said:

nolaegghead said:

ColbyLang said:

Anyone else realize that Pfizer owns the lab where the virus originated? Hmmmmm

Where is that a fact other than the conspiracy theory wack job Earth 2?

Hey man, Fox News. We report, you decide. 

PS, I know it’s a false statement. Just bored on a Monday. Seeing who would bite

I wouldn't think even Fox would promote that...but hey, it's 2020.

ColbyLang

nolaegghead said:

ColbyLang said:

nolaegghead said:

ColbyLang said:

Anyone else realize that Pfizer owns the lab where the virus originated? Hmmmmm

Where is that a fact other than the conspiracy theory wack job Earth 2?

Hey man, Fox News. We report, you decide. 

PS, I know it’s a false statement. Just bored on a Monday. Seeing who would bite

I wouldn't think even Fox would promote that...but hey, it's 2020.

They didn’t. Good topic on the thread. 

My SIL getting hers tonight (night shift RN) at her hospital. She’s recommending everyone she knows gets it

frazzdaddy

Never took a flu shot but this is a bit different. Put me down for a yupp.

nolaegghead

General statement:  There is no connection between autism and vaccinations.  There was a paper written years ago by a British scientist that failed peer review and was retracted.  People have been mining data trying to find that relationship and it has not been found to-date.  In absence of any scientific relationship between the two, the connection only exists outside of scientific circles as a junk science (not science) and conspiracy. 

I think most everyone knows this, just stating the obvious.

1voyager

Definitely will.

ColtsFan

Bosses wife is a pediatric NP in Btown. She's getting hers tomorrow via IU Health's deployment protocol.

I'll get one when it's available to me

Bellavista52

Yes, I will take it.

nolaegghead

PSA:  If you carry an EpiPen around with you, you should *NOT* get vaccinated without talking to your doctor.  If you are in a high risk group or working the front lines and really need the vaccination, your doctor will want to arrange for you to be monitored after the shot somewhere that can handle anaphylactic reactions.  Or they will recommend you don't get the shot.  Just talk to your doctor first.

nolaegghead

SWMBO is getting the shot around the 28th. 

johnmitchell

Can anyone back up the theory that taking it in the bum is more beneficial than the arm?

blind99

I am scheduled to get the vaccine Wednesday morning.  Barring Covid infection in the next 36 hours, it's go time. 

My biggest fear about an mRNA vaccine is that it doesn't work: the little liposomes break down before getting the RNA into my cells.  The idea is brilliant, though.  I'd rather let my body make the antigen.  Alternatively we have to infect a bunch of eggs, break it all up, inactivate it, filter it, THEN inject it.  mRNA is elegance.  

sure, there are legitimate questions about the vaccine.  What if they chose the wrong protein to target?  What if it wears off, or the virus mutates?  Well, one shot of Pfizer's vaccine shows the same reduction in infection as one dose of flu vaccine.  And two doses takes it to 95%.  Even if it's good for only a year, with enough people vaccinated we can get the numbers manageable.

I'm a little biased because I see firsthand how people suffer with this.  I would not wish a bad case of Covid on anyone.  Dying alone, unable to breath, is horrific.  Throw in the organ failure and systemic thrombosis and godspeed, you're gone.  I wouldn't wish a moderate case on anyone, either.  It is no bueno.  

Men do worse than women.  Older do worse than younger.  Overweight do worse than thin.  How's our forum sounding?  

I'll leave you with this, from results published in NEJM a few days ago.  The lines show the rate of Covid in each group, out to about 4 months.  I want to be on the red line.  And the crazy thing is that by two weeks, the lines diverge: a single dose of vaccine is helpful.  

nolaegghead

johnmitchell said:

Can anyone back up the theory that taking it in the bum is more beneficial than the arm?

I haven't heard that but I'm sure it's a pain in the as5.

nolaegghead

Great info @blind99

PigBeanUs

johnmitchell said:

Can anyone back up the theory that taking it in the bum is more beneficial than the arm?

Be more specific. Taking *what* in the bum?

Cornholio

I was talking to my rheumatologist about the vaccines a few weeks ago. Since my injections for psoriatic arthritis compromise my immune system I will wait for more feedback from her. In general patients who are taking Ustekinumab like I do have not had as bad of a reaction to COVID as expected for being immune compromised. The way it works to stop your immune system from attacking the body may actually be helpful against COVID but there’s not enough data to make any conclusions (at least there wasn’t a few weeks ago).

So yes I will take it but I will be working with my doctor to determine if/when I should. I am getting the Pneumovax 23 vaccination this week per her recommendation and I get the flu shot every year as well. 

blind99

nolaegghead said:

Great info @blind99

i'll report back wednesday.  shouldn't be too bad, but they say the 2nd dose is pretty unpleasant.  

frazzdaddy

PigBeanUs said:

johnmitchell said:

Can anyone back up the theory that taking it in the bum is more beneficial than the arm?

Be more specific. Taking *what* in the bum?

oh dear, and it's only Monday

EggObsessed

I will definitely take it as soon as it's available for me.

JethroVA

500 said:

If I was concerned about the the things I put in my body, I wouldn't drink alcohol or eat fatty meats.  I do both; and with drinking, to great excess, at times.  I'll take it.  

Yep.  I'm getting the vax because if the other crap I put into my body hasn't killed me yet, the vax surely won't hurt.  I am in a medium risk group and am more afraid of the long term cardiovascular effects.  This is one insidious disease.   That and I care for my elderly parents.   If I give it to them, they'll die. 

frazzdaddy

JethroVA said:

500 said:

If I was concerned about the the things I put in my body, I wouldn't drink alcohol or eat fatty meats.  I do both; and with drinking, to great excess, at times.  I'll take it.  

Yep.  I'm getting the vax because if the other crap I put into my body hasn't killed me yet, the vax surely won't hurt.  I am in a medium risk group and am more afraid of the long term cardiovascular effects.  This is one insidious disease.   That and I care for my elderly parents.   If I give it to them, they'll die. 

Ditto

Gulfcoastguy

I would take the Pfizer or Moderna vaccines in a heartbeat. As I see it though I probably won’t be offered it until Easter or so, 60 with 1 pre existing condition and no longer a critical employee. I already have spent an hour talking my parents into taking it as soon as offered. I described the likely side effects and to not let that convince them to skip the second shot. 

The AstraZeneca or Johnson & Johnson vaccines, I am not convinced of yet . We will have to have at least one of them at least in order to get everybody vaccinated by Labor Day though. The Pfizer and Moderna will only have enough vaccine for 150 million by mid summer.

sumoconnell

I’ll take it. 

PigBeanUs

To answer johnmitchell:

what the heck, I'll try taking it in the bum. 

Also

I will get the vaccine shot too.