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Covid science-y science

Legume
Legume Posts: 15,938
Just trying to lift a little above the political fray.

Interesting paper that just dropped on a potential treatment, studied here in a very sick population.

https://www.nejm.org/doi/full/10.1056/NEJMoa2007016

THANK YOU FOR YOUR ATTENTION TO THIS MATTER
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Comments

  • Gulfcoastguy
    Gulfcoastguy Posts: 7,451
    Not perfect but 80%of patients who go on the ventilator don’t make it on their own. So a definite improvement was found.
  • HeavyG
    HeavyG Posts: 10,380
    TL:DR
    Might be beneficial, but too many variables and too small a sample, with insufficient collection of some biological markers (e.g. viral load) to make any definitive pronouncements. Data does support further study.
    “Reality is that which, when you stop believing in it, doesn't go away.” ― Philip K. Diçk




  • caliking
    caliking Posts: 19,780
    I hope those results are on the mark. 

    I’m interested in seeing results from studies using convalescent serum. The big 3 hospitals in Houston are collecting serum from recovered COVID patients now. 

    #1 LBGE December 2012 • #2 SBGE February  2013 • #3 Mini May 2013
    A happy BGE family in Houston, TX.
  • Legume
    Legume Posts: 15,938
    HeavyG said:
    TL:DR
    Might be beneficial, but too many variables and too small a sample, with insufficient collection of some biological markers (e.g. viral load) to make any definitive pronouncements. Data does support further study.
    Yep, just a write up on a compassionate use program, the sickest subjects and no control arm.  It’s structured anecdotal evidence that leans positive, not a controlled trial.
    THANK YOU FOR YOUR ATTENTION TO THIS MATTER
  • Legume
    Legume Posts: 15,938
    caliking said:
    I hope those results are on the mark. 

    I’m interested in seeing results from studies using convalescent serum. The big 3 hospitals in Houston are collecting serum from recovered COVID patients now. 
    I believe I read somewhere that there are some very large collaborative trials starting or underway with convalescent serum.
    THANK YOU FOR YOUR ATTENTION TO THIS MATTER
  • frazzdaddy
    frazzdaddy Posts: 2,617
    edited April 2020
    Legume said:
    caliking said:
    I hope those results are on the mark. 

    I’m interested in seeing results from studies using convalescent serum. The big 3 hospitals in Houston are collecting serum from recovered COVID patients now. 
    I believe I read somewhere that there are some very large collaborative trials starting or underway with convalescent serum.
    @caliking So, how does that work? (I am a mechanic) is it compatible with all blood types?
    Xl bge ,LG bge, two 4' crusher cone fire pits. Weber Genisis gasser and 
    Two rusty Weber kettles. 

    Two Rivers Farm
    Moncure N.C.
  • CTMike
    CTMike Posts: 3,725
    I heard about this on NPR a week ago about a lab trial in Australia. Let’s hope it has legs:

    https://www.sciencedirect.com/science/article/pii/S0166354220302011
    MMBGE / Large BGE / XL BGE (Craigslist Find) / SF30x80 cabinet trailer - "Ol' Mortimer" / Outdoor kitchen in progress.  

    RECOVERING BUBBLEHEAD
    Southeastern CT. 
  • nolaegghead
    nolaegghead Posts: 42,109
    Remdesivir seems to have the most promise based on the science and anecdotal evidence.   Hope the clinical couple blind studies that are ongoing show it has a real therapeutic benefit.  So far all the drugs touted have been washouts. 
    ______________________________________________
    I love lamp..
  • Gulfcoastguy
    Gulfcoastguy Posts: 7,451
    What if Trump owns stock in Gilead?🤔
  • Legume
    Legume Posts: 15,938
    What if Trump owns stock in Gilead?🤔
    What if he does?  I guess I’m missing your point.
    THANK YOU FOR YOUR ATTENTION TO THIS MATTER
  • Spaightlabs
    Spaightlabs Posts: 2,349
    What if Trump owns stock in Gilead?🤔
    Here's the thing.  He is a somewhat wealthy guy.  As such he probs owns many stocks.

    Most likely mainly in restaurants that serve ketchup with well done steaks or food that comes in a bucket, but possibly some others.

    I don't care what he owns stock in, but I do care when he spouts opinions that are not based on reality or science about the efficacy of some treatment based on his ample gut.
  • Legume
    Legume Posts: 15,938
    Boom.  Nailed it.
    THANK YOU FOR YOUR ATTENTION TO THIS MATTER
  • caliking
    caliking Posts: 19,780
    Interesting and informative read, from the stack of mags that I'm never caught up with reading. 

    https://www.newyorker.com/magazine/2020/04/06/how-does-the-coronavirus-behave-inside-a-patient

    #1 LBGE December 2012 • #2 SBGE February  2013 • #3 Mini May 2013
    A happy BGE family in Houston, TX.
  • GATraveller
    GATraveller Posts: 8,207
    Interesting article @caliking.
    Thanks. 

    "Social media gives legions of idiots the right to speak when they once only spoke at a bar after a glass of wine, without harming the community [...] but now they have the same right to speak as a Nobel Prize winner. It's the invasion of the idiots."

                                                                                  -Umberto Eco

    2 Large
    Peachtree Corners, GA
  • bubbajack
    bubbajack Posts: 1,180
    HCQ and a Zpack, Zinc Phostphate have about a 98% rate in the small studies world wide and in rest homes. Protocol here in NC...and we have 35 deaths per million..

    I hope that we can have multiple ways to fight this. We do not have 2 years to play around.

    I am hoping we can have BB2021!
    I drink cheap beer so I can afford good bourbon.

    Salisbury, NC...... XL,Lx3,Mx2,S, MM, Mini BGE, FireDisc x2. Blackstone 22", Offset smoker, weber kettle 22"


  • caliking
    caliking Posts: 19,780
    bubbajack said:
    HCQ and a Zpack, Zinc Phostphate have about a 98% rate in the small studies world wide and in rest homes. Protocol here in NC...and we have 35 deaths per million..

    I hope that we can have multiple ways to fight this. We do not have 2 years to play around.

    I am hoping we can have BB2021!
    I thought this was the science/evidence based thread...

    but I definitely agree with paragraphs 2 & 3!

    #1 LBGE December 2012 • #2 SBGE February  2013 • #3 Mini May 2013
    A happy BGE family in Houston, TX.
  • JohnInCarolina
    JohnInCarolina Posts: 35,122
    bubbajack said:
    HCQ and a Zpack, Zinc Phostphate have about a 98% rate in the small studies world wide and in rest homes. 

    How are the exogeneous ketones doing?
    "I've made a note never to piss you two off." - Stike

    "The truth is, these are not very bright guys, and things got out of hand." - Deep Throat
  • lousubcap
    lousubcap Posts: 37,334
    Caught a news feed Sunday regarding a fast track vaccine being worked at Oxford in England.  Being a back-bencher it even sounded promising to me within the calendar year which would be a world record by several years.  Back to the Q entertainment.  
    Louisville; Rolling smoke in the neighbourhood.  Life is too short for light/lite beer!  Seems I'm livin in a transitional period. CHEETO (aka Agent Orange) makes Nixon look like a saint.  
  • bubbajack
    bubbajack Posts: 1,180
    Look it up...
    I drink cheap beer so I can afford good bourbon.

    Salisbury, NC...... XL,Lx3,Mx2,S, MM, Mini BGE, FireDisc x2. Blackstone 22", Offset smoker, weber kettle 22"


  • JohnInCarolina
    JohnInCarolina Posts: 35,122
    lousubcap said:
    Caught a news feed Sunday regarding a fast track vaccine being worked at Oxford in England.  Being a back-bencher it even sounded promising to me within the calendar year which would be a world record by several years.  Back to the Q entertainment.  
    Unlikely to be successful Frank.  But we can and will hope for the best.
    "I've made a note never to piss you two off." - Stike

    "The truth is, these are not very bright guys, and things got out of hand." - Deep Throat
  • caliking
    caliking Posts: 19,780
    bubbajack said:
    Look it up...
    I have. 

    #1 LBGE December 2012 • #2 SBGE February  2013 • #3 Mini May 2013
    A happy BGE family in Houston, TX.
  • DMW
    DMW Posts: 13,836
    caliking said:
    bubbajack said:
    Look it up...
    I have. 
    Well, are you a doctor or something?
    They/Them
    Morgantown, PA

    XL BGE - S BGE - KJ Jr - HB Legacy - BS Pizza Oven - 30" Firepit - King Kooker Fryer -  PR72T - WSJ - BS 17" Griddle - XXL BGE  - BS SS36" Griddle - 2 Burner Gasser - Pellet Smoker
  • Legume
    Legume Posts: 15,938
    DMW said:
    caliking said:
    bubbajack said:
    Look it up...
    I have. 
    Well, are you a doctor or something?
    Not a bricklayer.
    THANK YOU FOR YOUR ATTENTION TO THIS MATTER
  • caliking
    caliking Posts: 19,780
    DMW said:
    caliking said:
    bubbajack said:
    Look it up...
    I have. 
    Well, are you a doctor or something?
    I did stay at a Holiday Inn Exptess once...

    #1 LBGE December 2012 • #2 SBGE February  2013 • #3 Mini May 2013
    A happy BGE family in Houston, TX.
  • HeavyG
    HeavyG Posts: 10,380
    This is what happens when your boss tells everyone to just ignore the science/medical advice and get to work...
    I'm guessing that situations like this is also why that delightful human being, Moscow Mitch, is trying to get a bill thru Congress giving businesses immunity from liability for covid infections.

    “Reality is that which, when you stop believing in it, doesn't go away.” ― Philip K. Diçk




  • JohnInCarolina
    JohnInCarolina Posts: 35,122
    Saw that "Grandma Killer" is trending and... oh.. oh no... oh good Lord.  
    "I've made a note never to piss you two off." - Stike

    "The truth is, these are not very bright guys, and things got out of hand." - Deep Throat
  • GATraveller
    GATraveller Posts: 8,207
    edited May 2020
    Worth your time but heartbreaking. 
    https://apnews.com/b2a2add19ce7f4f75f42b29331034706

    "Social media gives legions of idiots the right to speak when they once only spoke at a bar after a glass of wine, without harming the community [...] but now they have the same right to speak as a Nobel Prize winner. It's the invasion of the idiots."

                                                                                  -Umberto Eco

    2 Large
    Peachtree Corners, GA
  • YukonRon
    YukonRon Posts: 17,319
    "Knowledge is Good" - Emil Faber

    XL and MM
    Louisville, Kentucky
  • Eoin
    Eoin Posts: 4,304
    lousubcap said:
    Caught a news feed Sunday regarding a fast track vaccine being worked at Oxford in England.  Being a back-bencher it even sounded promising to me within the calendar year which would be a world record by several years.  Back to the Q entertainment.  
    This is at initial trial stage. The problem is that politicians are looking for any good news and bigging up these possible solutions to avoid looking helpless. They are likely a long way away.

    Our 'Government' isn't doing a great job - poor communications, poor decision making, poor planning and responding slowly to changing circumstances. We also have a looming debacle with a contact tracing App - slow off the mark and then trying to design a new one from scratch instead of using what is proven.

    The 6 Ps are not much in evidence.