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I don't. You could probably get away with it in a sauce. However I wouldn't put it in a rub because the sugar is not only in rubs to change the flavor profile but also because slowly caramelizes and helps create a good bark which I would not think the artificial sweetener does.
Might be neat to do a side by side though and see what you think and report back.
Is there a reason you want to substitute the sugar? My sister always says that if you want sugar.. Eat sugar. Same goes for butter vs margarine. Sister is a dietitian
I've used powdered stevia once in my rub. Worked fine, but use sparingly. Not knowing the equivalence between stevia and sugar, I found that 1 Tbl of stevia made the rub way sweeter than 2 Tbl sugar.
From the perspective of eating a paleo diet, I would suppose xylitol or Splenda (tm), are just not right. While current evidence seems to indicate that refined carbohydrates are a problem, a paleo diet would seem to me to be just food that could be made without much fuss. Raw, or w. minimal cooking. I suppose honey can be dried and powdered. But for a pork butt, why not make incisions, and poke in raisins, or slices of dried apple? Or figs or dates.I've read advertising blurbs that say something like "made from sugar, so natural." Hmm, Henry Ford found a way to make auto bodies out of soybeans. Anyone want a bite?
Is there a reason you want to substitute the sugar? My sister always says that if you want sugar.. Eat sugar. Same goes for butter vs margarine. Sister is a dietitian well everyone has their own view on diets.. i eat primal/paleo. so all the raw oraganic butter and grassfed fat i can eat and veggies but no processed carbs/food or sugar. I do eat some sugar and have been with the current rubs i have but its always nice to try to find a better way.